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Paracetamol, particularly in combination with weak opioids, is more likely than NSAIDs to cause rebound headache (medication overuse headache), although less of a risk than ergotamine or triptans used for migraines.[26] Paracetamol is contained in many preparations (both over-the-counter and prescription-only medications)

10.1016/j.nantod.2020.100953 195 RuiS.SongL.LanJ.WangD.FengS.LuJ.et al (2023)

1 2 American Oil Chemists' Society (ed.)

Handle it gently Keep the vial out of direct sunlight and UV, store it upright, and avoid hard shaking

We've seen researchers try to get by with less, and it often ends in failure

Practitioners are responsible for subject screening, dosing, informed consent and clinical record-keeping