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I was surprised to discover that when applied to brow bone, it actually looks like Ive had an upper bleph by tightening up creased, drooping eyelids

MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)

doi:10.1007/s12015-025-10911-x

Nature 454 , 846851 (2008)

The potential of GHK as an anti-aging peptide

GHK-Cu is studied because it may tilt skin cell signaling toward repair, with more matrix building and less matrix breakdown in certain models