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8,136,137 With the continuous advancements of experimental techniques and sequencing technology (such as single-cell sequencing and spatial omics), significant strides have been made in comprehending the underlying mechanisms driving tumor progression

Pathria et al., 2018

Hegewisch-Becker S, Hanania EG, Fu S, Korbling M, Deisseroth AB, Andreeff M

Mice with hepatocyte-specific deletion of ERK5 (ERK5Hep) were fed with a high-fat diet (HFD) for 16 weeks

When the same research group tested oral formulations, they required 3-5 times higher doses to achieve comparable therapeutic effects

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