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Systemic side effects may include nausea, gastrointestinal upset, flushing, and, in rare cases, allergic reactions such as rash, hives, or anaphylaxis

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In the most recent audit, of the 24 sampled E&M services billed with modifier 25 and provided on the same day as intravitreal injections using the modifier, 22 were found to be improper, as the use of modifier 25 was not supported by documentation