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Reversely, the cell membrane protein transferrin (TF) typically binds extracellular iron ions in a trivalent form

The optimal number of clusters was determined using the Silhouette method, and clusters were based on a period of 112 months

It supports mitochondrial and antioxidant systems, leading to better ATP production, reduced oxidative stress, and more efficient cellular repair

Clear regulatory guidelines and early engagement with agencies are also being pursued to ensure that promising ferroptosis-based CVD therapies can enter clinical trials and, ultimately, patient care

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