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396,397 Interventions for Ulcerative colitis The progression of UC is a complex process that is attributed primarily to genetics and the environment and secondarily to a disturbance of the gut microbiota, 398,399 abnormal immunoregulation, 400 and psychological stress

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Extracellular vesicles secreted by Akkermansia muciniphila improve tight junction function through AMPK-dependent mechanisms, reducing intestinal permeability and attenuating high-fat diet-induced weight gain (97)

The top five bioactive compounds, phytofluene, naringin, hesperidin, zeta-carotene, and cis -phytoene, bind to the binding site of IL1RAP, with binding energy values of 10.23 (Figure 5A), 10.21, 10.19, 9.74, and 9.71 kcal/mol, respectively

It may also reduce inflammation markers in the gut

Schonbeck et al., 2001)