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The observation that DNA methylation can account for rather more of the variance in serum UA than genetic polymorphisms 32 indicates the strong potential of investigation into this and other epigenetic factors in relation to risk of PD and, of course, other disorders associated with UA

As cited above, research shows that selenium may protect against long-term damage to the thyroid gland for individuals with thyroid diseaseeither hypothyroidism or hyperthyroidism

doi: 10.1016/j.apsb.2020.09.015 96 LiuYLiuYYeSFengHMaL

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350 Notably, the modification of gut microbiota, BA metabolism and activation of intestinal TGR5 by dioscin treatment led to enhanced secretion of GLP-1 in both the intestine and brain of MPTP-treated mice

doi:10.1021/acsami.9b16119 77