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Effect sizes were Hedges g values (calculated using rank-transformed data), with non-central 95% Cis, from the 9 patients who performed the phase II

GLP-1 activation suppresses appetite and slows gastric emptying, while GIP signaling is thought to enhance energy expenditure, improve insulin sensitivity in adipose tissue, and reduce gastrointestinal side effects through central mechanisms

What neither has, and what no amount of rubric-building changes, is a published human trial proving it works as a fat-loss treatment

Whether weight matters for your specific formulation is a clinical judgment your prescriber makes with your medical history, not a rule you can infer online

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