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Oncotarget 6, 83398352

Peptide vaccines have been studied in combination with chemotherapy agents and drugs not intended to treat cancer, with promising results

Rucker J, Jafari H, Mantingh T, Bird C, Modlin NL, Knight G, et al

The rapid generation of O 2 and H 2 O 2 may mediate a further increase in cytosolic Ca 2+ [41] so elevating glucose metabolism via activation of specific Ca 2+ -sensitive metabolic enzymes (especially those located in the mitochondria), which results in generation of mitochondrial-derived metabolic stimulussecretion coupling factors (such as glutamate, citrate, NADPH and mitochondrially derived ROS) and promotion of insulin secretion (Fig