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In short, ascorbate functions as a Trojan horse through its conversion to DHA, and insidiously enters cancer cells via GLUT1 to promote the generation of intracellular ROS, which ultimately kills the cancer cell

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Despite recent developments in the field of metal-based catalytic drugs, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses 29

[DOI] [PubMed] [Google Scholar] 117.Lu J, Chew EH, Holmgren A