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Boddu P, Swaminathan M, Ravandi F, Garcia-Manero G, Borthakur G, Jabbour E, DiNardo C, Daver N, Jain N, Pemmaraju N, Jorgensen J, Wang S, Andreeff M , Cortes JE, Kantarjian H, Kadia T

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation

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326 In addition, the role of arginine methyltransferase (PRMT) in the regulation of tumorigenesis and development has also received extensive attention, and a variety of PRMT inhibitors have shown good anti-tumor activity in vitro and animal models, and a variety of drugs targeting type I PRMT and PRMT5 have been tested