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Norisoboldine Norisoboldine (NOR), the main isoquinoline alkaloid present in the dried roots of Radix Linderae, may have certain anti-RA activity (70, 71), which can improve synovitis and abnormal immune status of CIA mice, and inhibit the activation of RAW264.7 macrophages by down-regulating the MAPKs signaling pathway

Semax / Selank Semax acts primarily by modulating neurotrophin systems, especially enhancing Brain-Derived Neurotrophic Factor (BDNF) signaling and impacting neurotransmission to support neuroprotection and cognition

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ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation

Anencephaly and spina bifida is the most common type of NTDs