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However, because reopening will not be limited to adjusting performance year and benchmark year expenditures for ACO assigned beneficiaries but will also impact other potentially offsetting calculations including regional and national expenditure trends used to update ACO benchmarks, and because, in addition to the reopening, CMS will also adjust the historical benchmark calculated for a potential subsequent ( agreement period, the frequency of requests, and the net impact of any given request, are likely to be limited

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Subcutaneous adipose tissue (SAT) was collected for DNA methylation analysis (primary outcome)

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Ignoring the cause supplementation treats the deficiency but not the disease