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Identification of nsSNPs on the domains of GSR The InterPro 32 ( tool was used to identify the location of point mutations on the domains of glutathione-disulfide reductase protein, which can recognize motifs, active sites and domains of a protein

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mTORC1 contributes to protein translation, metabolism, and protein turnover, and mTORC2 is responsible for cell growth and migration 38

However, genetic loss of GCN2 or inhibition of GCN2 with GCN2-IN-6 did not influence the outcome of pairwise AA dropouts and -Met rescue of threonine deprivationassociated cell death (Fig S6AC)