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Comparison of Escherichia coli-asparaginase with Erwinia-asparaginase in the treatment of childhood lymphoid malignancies: results of a randomized European Organisation for Research and Treatment of Cancer-Children's Leukemia Group phase 3 trial

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The discontinuous and fenestrated endothelium in rapidly growing malignant tumors and the poor lymphatic system allow LNPs and internalized siRNAs greater accumulation and slower clearance in solid tumors, referred to as the enhanced permeation and retention (EPR) effect

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Originally published on Space.com

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Instead, these organs employ an amino acid transporter to absorb glycine, cysteine, and glutamate for intracellular de novo GSH synthesis

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William Shaw, PhD

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