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Mammalian polyamine metabolism and function

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They used three different mice models, the maximal electrical shock (MES) model of epilepsy, ionized (INH) induced model, and pentylenetetrazol (PTZ) model, and evaluated the effect of the stem bark extract against various parameters such as seizure onset time, duration of convulsions, as well as estimated the level of GABA in the brain using two different doses of 250 and 500 mg/kg and compared with the standard AEDs diazepam

(138) proved that paeoniflorin could significantly improve the symptoms of CIA rats, reduce the levels of pro-inflammatory factors (TNF-, IL-1 and IL-6), and down-regulate the expression of p-NF-B p65 and p-myosin-binding subunit (MYPT1)