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Immunoregulation Through the Mitochondrial Intermediate Succinate By producing NADH, the tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation, fueling complex I of the electron transport chain and eventually ATP generation

This urged us to unveil the relevance of PSPH genetic alterations and subsequent ser/gly metabolism deregulation in the pathogenesis of glioblastoma

Eklund, A., Nichols, T

This is achieved by the elimination of hydrogen peroxide primarily through the dual function of the same egg oxidase, and secondarily through cytoplasmic ROS scavengers, such as catalase and glutathione

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Table 1 Small molecule inhibitors that target various pathways in GBM