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The regulation of key enzyme activities by natural plant polysaccharides can contribute to the modulation and equilibrium of metabolites with specific neuroactive properties, thereby promoting TRP metabolism to 5-HT while inhibiting TRP metabolism to 3-HK ( Intervention with Polygonatum sibiricum polysaccharides (PSP) was found to downregulate TRP and 3-HK levels in the hippocampus of mice in a behavioral despair model (Wei et al., 2022)

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Synthetic control arms A statistical method used to estimate the outcomes of a treatment group in the absence of a traditional control group, wherein participants are not randomized to an active comparator or placebo, but data from such a group is constructed using either historical or external sources to closely resemble those undergoing treatment

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