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Oxidative stress can cause these complications by activating the hexosamine pathway, the advanced glycation end products (AGEs) pathway and the diacylglycerol (DAG)-protein kinase C (PKC) pathway ( Hyperglycemia decreases G6PD activity through the activation of protein kinase A (PKA) and increase of intracellular oxidative stress, leading to chronic kidney injury, and diabetic kidney disease (DKD) ( TKT plays an important role in preventing hyperglycemia-induced vascular cell dysfunction ( The Role of the PPP in Cancer The PPP is critical for cancer prevention and treatment because NADPH and R5P play important roles in regulating DNA damage response, metabolism, and proliferation in cancer cells

Recent studies have expanded its application to non-diabetic and heart failure patients, demonstrating its efficacy in reducing the risk of cardiovascular deterioration and mortality [223]

Lpez-Sanromn A, Esplugues JV, Domnech E

Franke A, McGovern DPB, Barrett JC, Wang K, Radford- Smith GL, Ahmad T, et al

S6D) and promote the degradation of PPAR through the ubiquitin-proteasome pathway [34]

References Nwozo, S