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However, physical forces such as shear stress, matrix stiffness, and interstitial flow are also major drivers and effectors of angiogenesis, and new research suggests that mechanical forces may regulate VEGFR-2 phosphorylation

doi: 10.1007/s10571-023-01411-y 88 LiDZhangZWangL

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Indeed, by analyzing the differential DNA methylation regions (epimutations) and genetic mutations (copy number variation: CNV), they demonstrate an increase in copy number variants associated with altered DNA methylation in the F3 generation (Skinner et al., 2015)