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Mice were randomly assigned to one of two groups: a vehicle control group (V-CNT) and a B12-supplemented group (SUPP)

Improvements can be immediate or take several days/weeks and last from days to weeks based on the individual and vitamin cocktail used

Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB

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This method allows for higher bioavailability compared to pills or powders, which must pass through the digestive system first, which means they often lose potency in the process

Adding a phosphate binder should be the last step , as it can cause constipation, which causes discomfort, and you want this binder to be a last resort or have something to go to when their CKD worsens and the Stage of CKD rises