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During the early phase of nerve injury, infiltrated macrophages are predominated by pro-inflammatory (M1) phenotypes and, subsequently, transit to an intermediate phenotype characterized by the co-expression of pro-inflammatory (M1) and pro-regenerative (M2) macrophage markers or predominant pro-regenerative (M2) phenotype [7]

Consensus on Clinical Practices of Treatment, Prophylaxis, and Long-Term Management of Vitamin B12 Deficiency Due to the lack of evidence on the comparative effectiveness and safety of different chemical forms of vitamin B12 (e.g., cyanocobalamin and methylcobalamin), the panelists agreed that evidence from randomized controlled trials is needed