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Moreover, apoptosis and cell death were reversed by downregulation of all apoptotic key markers reflected with decreased serum levels of ALP and AST toward their corresponding normal values, as well as histological signs of liver cell membrane stabilization and repair of hepatic tissue damage

Accordingly, VEGF-B segments 4548 and 7993, including binding residues Val48, Leu81, Ile83, Ser88, Gln89 and Leu90, and VEGF-A segment 8388, comprising binding residues Ile83, Lys84, Pro85, His86 and Gly88, were selected to be covalently linked into a single peptide

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These materials collectively indicate prospects for multiplexed diagnostics and combination therapy

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