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J Mol Endocrinol 63:R93R102

Effective means for evaluating the safety of mitochondria-targeting drugs has not been established, and the potential risk of toxic side effects needs to be focused on

Studies have shown that GCL is the main determinant of cellular glutathione levels since it catalyzes the first and rate-limiting step in glutathione synthesis 25

Meet Tom: A Story of Rediscovery Tom, 62, used to love playing golf with his buddiesbut lately, just getting through the front nine left him sore, winded, and frustrated

Oncogene mutations, such as those in c-MYC , KRAS , and p53 , regulate key enzymes involved in amino acid metabolism, which in turn affects tumor cell survival and proliferation