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This resulted in a significant decrease in fatal crashes

It means there is no established dosing standard, no agreed safety profile for reproductive use, and no clear proof it helps fertility outcomes

La dure thorique de ces rserves a t calcule sur la moyenne des pertes quotidiennes par excrtion biliaire, elles-mmes estimes entre 0,1 et 0,2 % des rserves totales (en tenant compte d'une rabsorption entro-hpatique elle-mme estime 50 %), partir de trs rares donnes obtenues par expriences aprs cholcystectomie [37]