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Indications for a direct connection between the nose and the CNS were discovered at the beginning of the last century [8], as researchers were able to show that substances injected into the subarachnoid space can reach the nasal mucosa [21]

Studies in healthy elderly individuals showed that Sermorelin administration could increase GH and IGF-1 levels toward more youthful ranges, with associated improvements in body composition (increased lean mass, reduced abdominal adiposity), sleep quality (enhanced slow-wave sleep), skin thickness, bone density markers, and subjective energy and vitality