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IRs (95% CI) in the U.S

The prevalence of glutathione in pharmaceutical applications, compared to its use in other sectors, is rooted in the critical need for precise and targeted therapeutic interventions

Disruption of ubiquitination could lead to mislocalization of proteins, accumulation of damaged or misfolded proteins, improper complex assembly, aberrant enzymatic activities, or inaccurate signal transductions, contributing to the development of human diseases, including cancers, autoimmune diseases, developmental disorders, metabolic syndromes, and neurodegeneration (Popovic et al

Kutuk O, Poli G, Basaga H

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Finally, regarding the substitution pattern on the indoles aromatic ring (C-6 and C-8), except for the introduction of a 6-CF 3 group (IC 50 = 6.46 M), the introduction of any other functional group led to toxic derivatives or derivatives with no leishmanicidal activity (Figure 11B)