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Besides passive diffusion across bilayer membranes, uptake or efflux via membrane transporter molecules is of high significance for compound absorption, distribution and elimination ( metabolite was observed to be subjected to facilitated uptake via GLUT-1 transporters into erythrocytes and endothelial cells ( For Pycnogenol constituents and metabolites, interactions with some specific structures, such as matrix proteins ( in vitro

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Cut-off values have been established for these biomarkers, but although they may help physicians identify the most appropriate time to start treatment for kidney damage, no corresponding treatment exists (84)

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