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Other ALDH2 approaches: Many investigational drugs showed promise in pre-clinical studies, including selective and reversible ALDH2 inhibitors (e.g., ANS-6637) and genetic targeting of liver ALDH2 messenger RNA to locally reduce hepatic ALDH2 expression (305, 306)

Additionally, a unique cluster of intratumoral CD8 + T cells expressing a putative gene signature of GSH metabolism (GMGS) was associated with clinical response and survival across several human cancers

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DOI: 10.1073/pnas.78.8.4767 52

The protein was immunolocalized in the epidermis and parenchyma of plerocercoid, and in the epidermis, parenchyma, uterus and egg shell of adult worm

Unlike metalloenzymes, most metal binding IDPs such as A have not evolved under selection to bind copper