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It is possible that mutation of the iron-binding histidines changes the tertiary structure of CDO in such a way that it is no longer recognized by an ubiquitin ligase, resulting in the disruption of cysteine-sensitive ubiquitination and degradation

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In pathological conditions, astrocytes undergo significant molecular and morphological remodeling, adopting either a detrimental A1 (neurotoxic) or beneficial A2 (neuroprotective) reactive state that, respectively, drives injury progression or promotes tissue repair [132, 133]

Passaro A, Mok T, Peters S, Popat S, Ahn M, De Marinis F

Total Glutathione (T-GSH)/Oxidized Glutathione (GSSG) Colorimetric Assay Kit Product Details Properties Images XX Li et al developed a novel nanoreactor activated by tumor microenvironment for chemiluminescence imaging, can be used for tumor resistance