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Disclosure of interest: No E-Posters - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.08 - COGNITION AND VASCULAR COGNITIVE IMPAIRMENT P2406 - ESOC25-1958 ASSOCIATION OF PARENTAL POST-STROKE COGNITIVE MEASURES AND INFLAMMATION IN MIDDLE-AGED OFFSPRING Jeremy Molad 1,2 , Roee Rothmann 2 , Hen Hallevi 1,2 , Oren Tene 1,2 , Aviva Alpernas 1 , Dror Shir 1 , Dana Niry 1 , Muhamad Hawwari 1 , Einor Ben Assayag 1,2,3 1 Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel, 2 Tel Aviv University, Tel Aviv, Israel, 3 Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel Background and Aims: Both parental stroke and parental Alzheimer's Disease (AD) have been related to increased risk of disease incidence in the offspring

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Consequently, STING activation promotes the lysosomal turnover of GPX4 in neurons experiencing concurrent inflammatory stimulation and excitotoxic insult (163)

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