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Nonteratogenic Effects Fetal/Neonatal Adverse Reactions Use of opioid analgesics for an extended period of time during pregnancy for medical or nonmedical purposes can result in physical dependence in the neonate and neonatal opioid withdrawal syndrome shortly after birth

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Common Symptoms of a Sulfa Allergy Can Include: Skin rashes or hives (most common) Fever Swelling of the face, mouth, or tongue Stomach cramps In severe cases, anaphylaxis Drugs commonly linked to Sulfa Allergy: Antibiotics Sulfamethoxazole (Co-trimoxazole, Bactrim, Septra) Sulfadiazine Sulfisoxazole Anti-inflammatory / Autoimmune Sulfasalazine Dapsone Diuretics Thiazides (Hydrochlorothiazide, Chlorthalidone, Indapamide) Loop diuretics (Furosemide, Bumetanide, Torsemide) Carbonic anhydrase inhibitors (Acetazolamide, Dorzolamide, Brinzolamide) Antidiabetic agents Sulfonylureas (Glibenclamide, Glipizide, Glimepiride, Gliclazide) Others Celecoxib (COX-2 inhibitor NSAID) Probenecid Key takeaway: Not every patient with a sulfa allergy will react to all sulfonamide drugs but vigilance saves lives

Shen, L., Weber, C

2021 Dec 1 [cited 2024 Nov 23];12(1):412