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Abbreviations ADL: Activities of daily living ANOVA: Analysis of variance BMI: Body mass index (kg/m 2 , kilograms per meter squared) BML: Bone marrow lesion BMAC: Bone marrow aspirate concentrate DEGs: Differentially expressed genes EKOA: Early-stage knee osteoarthritis HTO: High tibial osteotomy IQR: Interquartile range KOOS: Knee injury and osteoarthritis outcome score MOAKS: Magnetic resonance imaging osteoarthritis knee score MSCs: Mesenchymal stem cells MRI: Magnetic resonance imaging OA: Osteoarthritis OA-BMLs: Osteoarthritis-associated bone marrow lesions OARSI: Osteoarthritis research society international PRP: Platelet-rich plasma QOL: Quality of life SD: Standard deviation SRA: Sport and recreation activities TKA: Total knee arthroplasty TKR: Total knee replacement UKA: Unicompartmental knee arthroplasty VAS: Visual analog scale WOMAC: Western ontario and mcmaster universities osteoarthritis index References Moradi K, Kubassova O, Carrino JA

Nanoparticles may also trigger local or systemic immune responses