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Furthermore, 2-DG-mediated inhibition of glycolysis effectively reverses various electrophysiological alterations induced by epilepsy, suggesting that targeting lactate metabolism pathways could be a promising approach for the development of novel antiepileptic drugs [195] (Supplemental Table 2)

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Wherever required, medium was supplemented with 100 g/ml ampicillin

doi: 10.15252/embr.202153085 2 MareiHEAlthaniAAfifiNHasanACaceciTPozzoliGet al