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Enzymatic halogenation is complementary to other synthetic biology techniques, such as genetic code expansion and leveraging reactivity of amino acid side chains for the installation of halogen handles in peptides and proteins [63, 64]

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If we compare B12 adenosylcobalamin with the synthetic cyanocobalamin form, conversion seems to be the biggest potential issue when it comes to bioavailability and absorption: all forms of B12, once ingested, have to be broken down to their core cobalamin molecule, but cyanocobalamin will have to be transformed into adenosylcobalamin and methylcobalamin first

Ollerenshaw S, Jarvis D, Woolcock A, Sullivan C, Scheibner T