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The development of smart drug delivery systems for treating diabetes, incorporating glucose-sensing components such as glucose-binding proteins, glucose oxidase, and phenylboronic acid, together with advanced carriers such as hydrogels, microgels, and nanoparticles, has ensured precise, safe, and efficient insulin delivery

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Next, we investigated whether UPRmt activation is required for the lifespan extension observed on the mutant diets

Taken together, our study demonstrates how in silico drug target prediction based on metabolic modelling can be a useful complement in the selection of tailored treatments to improve the therapeutic outcome of melanoma patients especially for those that relapse or do not respond to current melanoma treatments

NAC group (rats were injected intraperitoneally with MTX on day 7 plus NAC 500 mg/kg/day throughout the experiment by oral gavage, plus Kolliphor EL from day 1- day 10) (Li et al., 2018