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Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu(2+)

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Moreover, HIF expression has been observed in chondrocytes and osteoclasts, indicating its ubiquitous presence in synovial tissues (129)

doi: 10.1371/journal.pone.0025792

Strategies to address this include designing biocompatible dendrimers, adjusting surface charges, and applying chemical modifications to mitigate toxicity for clinical applications [201]