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These developments reinforce an emerging need for systematic criteria to guide the rational selection of VLP formats tailored to distinct pathogen targets and immunological objectives

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A clumped peptide is not necessarily degraded, but moisture exposure increases the likelihood of other degradation pathways

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Mechanistic studies were conducted using metabolomic approaches, molecular docking, cellular thermal shift assay, Western blot, immunofluorescence, and Nrf2-knockdown assays