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Vitamin B12 deficiency: serious consequences

[DOI] [PMC free article] [PubMed] [Google Scholar] (164).Usman WM

Elevated homocysteine levels, also known as homcysteinemia, often signpost B12 deficiency although the absence of folic acid may also be a cause

For instance, lysosomal dysfunction in Fabry disease, a rare X-linked lysosomal disorder characterized by a buildup of globotriaosylceramide (Gb3) due to a deficiency of the lysosomal enzyme, alpha-galactosidase (GLA), has shown a decline in mitochondrial function and mitochondrial energy metabolism in renal cells [27]