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Over the years, almost half of the people in the study had overdosed by accident, Lee found, not by trying to kill themselves

These include tests for hemoglobin, calcium, phosphate, parathyroid hormone, albumin, potassium, and bicarbonate levels

[DOI] [PMC free article] [PubMed] [Google Scholar] (217).Son S

These factors can all contribute to the HIF stabilization under normoxic conditions in tumors and should be considered for future therapeutic approaches

Moreover, recent studies suggest that the induction of cellular senescence, rather than the promotion of apoptosis through radiotherapy or chemotherapy, might be the main mechanism for impairing the self-renewal capacity of cancer cells, particularly in the context of solid tumors [55]

Since immune cell trafficking into the CNS is tightly regulated by the blood brain barrier which selectively only allows entry of immune cell subsets required for immune surveillance (80), it remains unknown if CAR-T would efficiently reach senescent cells in the brain parenchyma