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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007

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In fact, before the recognition of glutamate transport activities, VGLUT1 and VGLUT2 were originally cloned as plasma membrane Na + -dependent inorganic phosphate transporters, given that their heterologous expression stimulates Na + /Pi co-transport into Xenopus oocytes (Ni et al., + -dependent phosphate transport (Juge et al., + -dependent Pi transport into SVs, which competes with glutamate transport (Preobraschenski et al., + exchange in SVs, which would convert pH to , thereby facilitating the -driven glutamate transport (Preobraschenski et al., Despite accumulating in vitro evidence from mechanistic insights into glutamate transport modulation by various ions, the physiological relevance of the foregoing biochemical observations in living synapses is largely unexplored, mainly due to technical constraints in manipulating and quantitatively measuring glutamate and various ion concentrations in the cytoplasm and in vesicle lumens

Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo

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10.1016/j.molcel.2015.06.011 32 GaoM.YiJ.ZhuJ.MinikesA