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Weeks 5 to 8: building tolerance (0.50 mg per week) The first dose increase

As they also demonstrated that PKC mediated morphine-induced MOR desensitization, it can be inferred that PKC would phosphorylate MOR at other sites than S363, T370, and S375

There samples were prepared by diluting 1:10 (volume/volume), using 2% HNO 3 immediately prior to analysis

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Urban et al., 2004)

*Correspondence: Frederic Michon [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers