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While pineal melatonin regulates the circadian rhythms, extra pineal melatonin performs various functions beyond its primary role, which includes acting as an antioxidant, stimulating the production of endogenous antioxidant enzymes, scavenging free radicals, and playing a homeostatic role within mitochondria (ArandaMartnez et al

Instead, tamoxifen binding to ABCB1 blocks its ability to transport other xenobiotics 72

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It is therefore unsurprising that many antioxidant food sources have been evaluated for their ability to scavenge RONS and avert oxidative stress

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