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Only eight conserved enzymes are sufficient for the biosynthetic pathway of all three BCAAs, including four branched-chain aminotransferases (IlvB/N, IlvC, IlvD, IlvE) that are conserved in the synthesis of all three BCAAs

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In addition, treatment with folic acid alone, in combination with vitamin B12, significantly reduced Hcy levels in SOD1 G93A mice, delayed disease onset, reduced motor neuron loss, and prolonged survival