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Utilizing two discrete murine HCC models, we found that myeloid-specific deletion of Samhd1 promotes HCC progression through increased PD-L1 expression and CXCL1/2-mediated recruitment and activation of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs)

Snawder JE, Roe AL, Benson RW, Roberts DW (1994) Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity

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Groh AMR, Fournier DE, Battie MC, Seguin CA

Treatment: 1 RCT (n=240) suggests possible benefit for CIPN treatment (low certainty)

doi: 10.1021/acs.jmedchem.0c02154 178 SandnerPFollmannMBecker-PelsterEHahnMGMeierCFreitasCet al