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The key inductive role of metabolic activation in toxicity is highlighted, and frequently toxic functional groups of toxic natural products were summarized

mTORC1 beyond anabolic metabolism: regulation of cell death

The shift in genetic interaction following treatment with exogenous signals or environmental stimuli, which alters the regulatory dynamics between genes, is not unprecedented

When pigment particles enter the trabecular meshwork endothelial cells, they can gradually lead to pigment overload and death of the trabecular meshwork cells

The secreted IL-10 cytokine values measured in the supernatant collected from cells stimulated with LPS and treated with the test products are reported in Table 3, which are expressed in terms of percentage (%) with respect to the cytokine level measured in the supernatant collected from control cells, stimulated with LPS, and incubated with the medium alone