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Although tacrolimus is apparently more efficacious in azathioprine non-responders than MMF, it is seldom used as a second-line agent considering the need for drug-level monitoring, higher cost, and associated toxicity [94, 113, 114]

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Kidney Dysfunction: In chronic kidney disease (CKD) or renal failure, the bodys ability to filter and excrete B12 may be compromised, leading to accumulation in the blood 8

doi: 10.1515/hc-2013-0141 178 JacquesS