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A literatura mais ampla sobre terapias biolgicas em medicina esportiva, conforme revisada por Andia e Maffulli (2018), ressalta a heterogeneidade e a experincia clnica limitada com novos produtos biolgicos, incluindo peptdeos como o TB-500.Os autores observam que, embora as terapias regenerativas sejam cada vez mais utilizadas na prtica clnica, faltam dados clnicos significativos sobre segurana e eficcia para muitos agentes , e h uma necessidade urgente de monitorizao e comunicao sistemticas de segurana

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