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GLP-1 Receptor Agonists Semaglutide and tirzepatide are technically peptide-based therapeutics

ROC analysis based on pathway scores revealed that pathways such as alanine, aspartate, and glutamate metabolism, inositol phosphate metabolism, and mitochondrial beta-oxidation of unsaturated fatty acids exhibited an AUC greater than 0.8 in the PBMC data (Table S16)

First of all, intracellular iron generally exists in the form of Fe 2+ , which can produce OH through the Fenton reaction, and then react with polyunsaturated fatty acids in the plasma membrane to produce ROS, resulting in iron-regulated death

This combination is effective for SIFO as well

Notably, recent work has shown that C

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