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Regarding the nutraceutical abilities of cannabis by-products, various outcomes of their inclusion to basal feed have been hypothesized, includes a decrease in the occurrence of tibia deformation in egg-laying chicks and hens, an enhanced serum lipid profile, a protective impact against the onset of hepatic disease, an anti-microbial activity, an improvement in anti-oxidative systemic condition, and an anti-inflammatory action (116120)

In the end of 20th century, it was shown that MEL increased the concentration of total, free and esterified cholesterol and decreased the concentration of non-esterified fatty acids in the blood of rats

Richardson TG, Wang Q, Sanderson E, Mahajan A, McCarthy MI, Frayling TM, et al

doi:10.1111/aos.13662 Bains VK, Bains R

10.1172/jci.insight.134221 45 IndelicatoE.NachbauerW.EigentlerA.AmprosiM.Matteucci GotheR.GiuntiP.et al (2020)

demonstrated that HBO upregulated the expression of connexins, such as occludin and zonula occludens-1 (ZO-1), in hypoxic cells, suggesting that HBO helps maintain the integrity and permeability of the BBB[85]